Relationship of symptom frequency and symptom-rhythm correlation to arrhythmia type and time to detection: Insights from ambulatory electrocardiogram monitoring in over 1 million patients

Authors: Anthony J. Battisti, PhD, Relana Pinkerton, PhD, Vladimir Fokin, PhD, Brent Wright, RN, Jay Alexander, MD, Ronald G. Berger, MD, Mintu P. Turakhia, MD

Summary:

Retrospective analysis of 1,100,337 Zio Monitor or Zio XT monitors with looking at symptom rhythm correlation.

Key Findings:

The median time to actionable arrhythmia was >48 hours, regardless of symptom frequency suggesting that traditional Holters may miss clinically meaningful events, even in patients with daily symptoms.

60% of actionable arrhythmias detected after 48 hours.

Only 18% of patients with arrhythmias had symptoms that aligned with an event; even daily-symptom patients had <50% correlation—highlighting that symptoms are an unreliable guide to underlying rhythm.

Arrhythmias with highest symptom rhythm correlation were AF (43.1%), isolated PAC (34.9%), isolated PVC (32.5%).

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